Day Time Sleep Alters Human Transcriptome

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If someone sleeps in a mistimed cycle, then their the genes which express in a 24-hour rhythm get reduces. The gens which get decreased primarily involves in the process of translation and transcription. Mistimed sleep or Day Time Sleep also contributes to the various psychological effects of jet lag and shift work. If someone delays their sleep time by three or for hours, they lead to a reduction in the six-fold reduction in the circadian rhythms. It also reduces the human blood transcriptome to 1 % but not affects the centrally driven circadian rhythm.

Day Time Sleep Alters Human Transcriptome
Day Time Sleep Alters Human Transcriptome
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Research By Nathaniel Kleitman About How Day Time Sleep Alters Human Transcriptome

In the year 1930 and 1940, the famous circadian research pioneer did research on himself. He found that when he followed a sleep-wake cycle of 28 hours, his body temperature did not fluctuate. But the body temperature fluctuates when he makes a 24-hour sleep cycle. Another researcher, Derk-Jan-Dijk, states that when someone does not sleep at the correct time of the day, their amplitude reduces. He also states that disturbing rhythms tend to underlie many problems. The people who work as per the shift or travel in long journey planes experience these problems of jetlag and shiftwork.

Research By Derk-Jan-Dijk On How Day Time Sleep Alters Human Transcriptome

Dijk, who works a sleep psychologist at the University of Surrey along with another researcher, conducts research. They invited 22 volunteers to their clinical research lab for three days, and they delayed the participants to sleep by four hours. As a result, the volunteers slept during the day time, and Dijk and others took their blood samples at regular intervals. By taking the blood samples, they microarrays by analyzing the transcripts. The researcher found that there was a significant impact on the timing of the transcripts.

Day Time Sleep Alters Human Transcriptome
Day Time Sleep Alters Human Transcriptome

Statement Of Co-Author Simon Archer

Simon Archer, the molecular biologist and co-author of the Dijk research works as a sleep geneticist at Surrey. He found that at the beginning of the experiment, nearly 6.5% of the participants followed a 24 hours rhythm. As a result, it was consistent along with the different estimates of the circadian gene expression. Similarly, at the end of the day, only 1% of the volunteer’s genes reflected the cyclical expression. Dijk stated that this ratio was quite a reduction in the cyclical expression. Moreover, it proves that the amplitude of psychological manifestations decreases when sleeping time delays. Hence, day time sleep alters human transcriptome.

Factors Affecting The Loss Of Rhythmicity

 The reduction in the rhythmicity in an individual can get decrease by numerous factors. The foremost factor includes the decrease in the amplitude of genetic expression cycling. It also consists of the shift in the timing of expression of the cycle. Thus, in this way, the day time sleep alters the human transcriptome. Some of the genes shift in the way which tends not to be circadian but bimodal. Both the circadian and bimodal genes got to express in the day time and get disrupted in the night.

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